Abstract
Metabolic syndrome (MetS) is associated with increased risk of carotid atherosclerosis.To estimate the frequency of MetS in patients with symptomatic carotid atherosclerotic disease, and to compare clinical, biochemical and ultrasonographic characteristics of patients with and without MetS.Cross-sectional study of 657 consecutive patients (412 males) with symptomatic carotid atherosclerotic disease. Carotid atherosclerosis was estimated by high resolution B-mode ultrasonography. National Cholesterol Education Program (NCEP) M criteria were used for estimation of MetS.Metabolic syndrome was present in 55.6% of studied patients. Among patients with metabolic syndrome there was a significantly higher proportion of women, and mean values of body weight, body mass index, waist circumference, percentage of body fat, systolic and diastolic blood pressure, serum triglycerides, total cholesterol and glucose were significantly higher. Mean values of high density lipoprotein cholesterol and alcohol consumption were significantly lower in patients with MetS. No differences between patients with or without MetS, were observed for age, smoking, mean values of low density lipoprotein cholesterol, high sensitive C-reactive protein and fibrinogen, and for degree of carotidstenosis or severity of clinical manifestations.Half of these patients with carotid stenosis have features of the metabolic syndrome.
Highlights
Metabolic syndrome (MetS) is associated with increased risk of carotid atherosclerosis
According to the National Cholesterol Education Program (NCEP) criteria, the age adjusted prevalence of the MetS in the US population was estimated at 23.7%, and increased to 43.5% in adults who were older than 60 years[6]
waist circumference (WC) and percent of body fat are more important than Body Mass Index (BMI) in predicting cardiovascular events and their consequences[22], and obesity expressed by WC was recommended as the most important risk factor for cardiovascular events[6]
Summary
Metabolic syndrome (MetS) is associated with increased risk of carotid atherosclerosis. Aim: To estimate the frequency of MetS in patients with symptomatic carotid atherosclerotic disease, and to compare clinical, biochemical and ultrasonographic characteristics of patients with and without MetS. Material and methods: Cross-sectional study of 657 consecutive patients (412 males) with symptomatic carotid atherosclerotic disease. Carotid atherosclerosis was estimated by high resolution B-mode ultrasonography. Mean values of high density lipoprotein cholesterol and alcohol consumption were significantly lower in patients with MetS. No differences between patients with or without MetS, were observed for age, smoking, mean values of low density lipoprotein cholesterol, high sensitive C-reactive protein and fibrinogen, and for degree of carotid stenosis or severity of clinical manifestations. (Key words: Carotid artery diseases; High density lipoprotein cholesterol; Metabolic syndrome) Conclusion: Half of these patients with carotid stenosis have features of the metabolic syndrome (Rev Méd Chile 2009; 137: 329-36). (Key words: Carotid artery diseases; High density lipoprotein cholesterol; Metabolic syndrome)
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