Frequency and Causes of Primary and Secondary Hyperparathyroidism in Patients Treated with Surgery at the University Clinical Hospital Mostar

Abstract

Background. The aim of this study was to investigate the causes of hyperparathyroidism and whether there is a difference between the sexes. An additional goal was to determine the incidence of primary and secondary hyperparathyroidism and the most common surgical method of treatment.Subjects and methods: 56 subjects were included in the study, of which 49 were women and 7 were men with diagnosed hyperparathyroidism. Subjects were patients who were treated endocrinologically and had elevated serum PTH (>7 pmol/L) as well as elevated Ca values (>2.6 mmol/L). The parameters considered are: age, sex, primary or secondary hyperparathyroidism, the most common surgical method of treatment.The results: The study included 56 respondents, of whom 49 women and 7 men. All respondents had a diagnosis of hyperparathyroidism. Statistically, a significantly higher proportion of female sex than men with primary hyperparathyroidism was diagnosed (χ2 = 8.64; s.s = 1; P = 0.003). The youngest patient was 40 years old and the oldest 92 years. The average age was 63 years.Most of the subjects in our study who had hyperparathyroidism also had parathyroid adenoma (χ2 = 6.74; s.s. = 1; P = 0,009).The most common surgical procedure was partial parathyroidectomy, with almost the same ratio between women and men. There were no differences in surgical procedures with respect to sex (χ2 = 1.25; s.s. = 1; P = 0.262).Parathyroidectomy of the lower and upper left as well as the lower and upper right parathyroid glands was equally common in our study (Table 4).Conclusion. The incidence of primary hyperparathyroidism was higher than secondary. Primary occured more frequently in females while secondary hyperparathyroidism occured equally in both sexes. The most common cause of primary hyperparathyroidism was parathyroid adenoma, and secondary chronic renal failure. The most common surgical procedure was partial parathyroidectomy. Parathyroidectomy of the lower and upper left as well as the lower and upper right parathyroid glands was equally common.