Abstract
Radiographic contrast material causes a variety of complications and reactions. In an attempt to minimize these events, alternative contrast agents have been developed, which either reduce the osmolality per iodine molecule, or reduce the number of charged particles in solution, or both. 1–8 Reduction of charged particles in solution makes some of the newer agents less chemotoxic than older ionic agents. 5,6,9 It has been demonstrated that the nonionic contrast agents have fewer hemodynamic and electrophysiologic effects than their ionic counter-parts. Myocardial contractility and vascular motor tone are less affected by the newer agents, as are heart rate and myocardial depolarization and repolarization. 1,4,6,7 It has been shown that nonionic agents such as iohexol and iopamidol cause fewer allergic, “anaphylactoid” reactions than standard ionic agents. 8,9 Little data compare the incidence of reactions with a low osmolar nonionic agent such as iohexol with the low osmolar ionic dimer, ioxaglate. The purpose of this study was to examine the occurrence of such events in a group of patients treated at the same institution with 1 or the other of these agents over the same time period under similar circumstances.
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