Abstract
BackgroundThe probiotic strain Lactobacillus plantarum 299v has earlier been shown to increase iron absorption when added to foods. However, it is not known if the same probiotic strain in a freeze-dried format included in a capsule increases the iron absorption.ObjectiveThe aim of this study was to test the hypotheses that non-heme iron absorption from a light meal is promoted by a simultaneous intake of freeze-dried Lactobacillus plantarum 299v (Lp299v, DSM 9843).Study designWith a single blinded placebo controlled sequential design, iron absorption from a light breakfast meal administered with or without capsules containing 1010 cfu freeze-dried Lp299v was studied in healthy female volunteers of fertile age. The methodology used was a double isotope technique (59Fe and 55Fe). Two studies were performed using the same protocol.ResultsIn study 1, the absorption of iron from a meal without Lp299v was found to be 17.4 ± 13.4%, and from an identical meal with Lp299v was found to be 22.4 ± 17.3% (mean ± SD). This difference was statistically significant (p = 0.040, n = 14).In study 2, the absorption of iron from a meal without Lp299v was found to be 20.9 ± 13.1%, and from an identical meal with Lp299v found to be 24.5 ± 12.0% (mean ± SD, n = 28), which again was statistically significant (p = 0.003).ConclusionFreeze-dried Lp299v enhances the absorption of iron when administered together with a meal with a high iron bioavailability.Trial registrationClinicalTrials.gov Identifier: NCT02131870
Highlights
Iron deficiency is the most common nutrient deficiency in the world, and is primarily present in women of reproductive age, who are at higher risk of developing iron deficiency because of iron losses during menstruation [1]
The probiotic strain Lactobacillus plantarum 299v has earlier been shown to increase iron absorption when added to foods
It is not known if the same probiotic strain in a freeze-dried format included in a capsule increases the iron absorption
Summary
Iron deficiency is the most common nutrient deficiency in the world, and is primarily present in women of reproductive age, who are at higher risk of developing iron deficiency because of iron losses during menstruation [1]. Iron deficiency is not the only cause of anemia, the WHO estimates that iron deficiency is responsible for approximately 50% of all anemia cases [6] This approximates to 1 billion cases of iron-deficiency anemia worldwide. The probiotic strain Lactobacillus plantarum 299v has earlier been shown to increase iron absorption when added to foods. It is not known if the same probiotic strain in a freeze-dried format included in a capsule increases the iron absorption
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