Abstract
PurposeTo develop and evaluate a novel non-ECG triggered 2D magnetic resonance fingerprinting (MRF) sequence allowing for simultaneous myocardial T1 and T2 mapping and cardiac Cine imaging. MethodsCardiac MRF (cMRF) has been recently proposed to provide joint T1/T2 myocardial mapping by triggering the acquisition to mid-diastole and relying on a subject-dependent dictionary of MR signal evolutions to generate the maps. In this work, we propose a novel “free-running” (non-ECG triggered) cMRF framework for simultaneous myocardial T1 and T2 mapping and cardiac Cine imaging in a single scan. Free-running cMRF is based on a transient state bSSFP acquisition with tiny golden angle radial readouts, varying flip angle and multiple adiabatic inversion pulses. The acquired data is retrospectively gated into several cardiac phases, which are reconstructed with an approach that combines parallel imaging, low rank modelling and patch-based high-order tensor regularization. Free-running cMRF was evaluated in a standardized phantom and ten healthy subjects. Comparison with reference spin-echo, MOLLI, SASHA, T2-GRASE and Cine was performed. ResultsT1 and T2 values obtained with the proposed approach were in good agreement with reference phantom values (ICC(A,1) > 0.99). Reported values for myocardium septum T1 were 1043 ± 48 ms, 1150 ± 100 ms and 1160 ± 79 ms for MOLLI, SASHA and free-running cMRF respectively and for T2 of 51.7 ± 4.1 ms and 44.6 ± 4.1 ms for T2-GRASE and free-running cMRF respectively. Good agreement was observed between free-running cMRF and conventional Cine 2D ejection fraction (bias = −0.83%). ConclusionThe proposed free-running cardiac MRF approach allows for simultaneous assessment of myocardial T1 and T2 and Cine imaging in a single scan.
Highlights
Cardiac Magnetic Resonance (CMR) imaging has become a key noninvasive diagnostic tool to assess anatomical structures, characterize myocardial tissue and evaluate functional and mechanical properties of the heart [1]
To develop and evaluate a novel non-ECG triggered 2D magnetic resonance fingerprinting (MRF) sequence allowing for simultaneous myocardial T1 and T2 mapping and cardiac Cine imaging
We propose a novel “free-running” Cardiac MRF (cMRF) framework for simultaneous myocardial T1 and T2 mapping and cardiac Cine imaging in a single scan
Summary
Cardiac Magnetic Resonance (CMR) imaging has become a key noninvasive diagnostic tool to assess anatomical structures, characterize myocardial tissue and evaluate functional and mechanical properties of the heart [1]. A parametric map is obtained by fitting the reconstructed images to the corresponding exponential relaxation model on a pixel-wise basis. These techniques require longer acquisition times than conventional qualitative (e.g. T1-weighted, T2weighted) MR imaging. Usually required to investigate the variety of clinical manifestations of the disease, are acquired sequentially, further increasing the scan time. These measurements are susceptible to system imperfections and other confounding factors (e.g. inter-parameter dependency)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
