Abstract
A kinetic analysis has been carried out for a cascade of intramolecular oxidation reactions of free radicals generated in the redox reactions of substituted cyclohexyl endoperoxides (15 compounds) with the Fe2+ ion. Each radical conversion reaction has been characterized by its enthalpy, activation energy, and rate constant. Kinetic characteristics have been calculated by the intersecting parabolas method. Depending on their structure, cyclohexyl endoperoxides generate one to three radicals. There is a linear empirical correlation between the number of radicals generated by a peroxide and its molar antimalarial activity (IC50/M, where M is the molar mass of the peroxide). The peroxides that generate no more than one radical show no antimalarial activity.
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