Abstract
The candidate antifungal drug efinaconazole is proving effective against toenail infections. The drug diffuses relatively freely through nails and binds less strongly to keratin than do other topically applied antifungal drugs, leaving it free to fight the fungus, according to Keita Sugiura of Kaken Pharmaceutical of Kyoto, Japan, and his collaborators. “This study suggests that … low keratin affinity is needed for favorable penetration and retention of antifungal activity within the nail matrix,” he says. Details appeared online 21 April 2014 and will be printed in the July 2014 Antimicrobial Agents and Chemotherapy.
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