Abstract
Lee et al1 have resurrected the free thyroxine index (FT4I) against modern analog-type (labeled analog/labeled antibody) free thyroxine (FT4) assays for diagnosis in pregnancy. This harkens back 40 years to a more innocent era, when shortcomings in thyroid hormone uptake methods were scarcely understood. All authentic FT4 assays must rigorously obey the law of mass action when measuring free hormone.
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