Abstract
AbstractFlexible neural electrodes integrated on micrometer‐thick polymer substrates offer important opportunities for improving the stability of neuronal activity recordings during cognitive processes. However, the bending stiffness of micrometer‐thick polymer substrates is typically two orders of magnitude higher than that of nanofilm electrodes, making it a limiting factor in electrode‐tissue interfacings. Here, this limitation is overcome by developing self‐assembled nanofilm electrode arrays (NEAs) that consist of high‐density, free‐standing gold nanofilm electrodes. Chronically implanted NEAs can form intimate and innervated interfaces with neural tissue, enabling stable neuronal activity recordings across multiple brain regions over several months. As an application example, the activities of the same neuronal populations are tracked across odor discrimination reversal learning and it is illustrated how dorsal striatal neurons represent and update stimulus‐outcome associations across multiple timescales. The results underscore the potential of free‐standing nanoscale materials for interfacing biological systems over long terms.
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