Abstract
Cerebral palsy caused by perinatal insult is a frequent cause of static encephalopathy, but metabolic or genetic disorders can present with similar nonspecific features. A 6-year-old boy was evaluated for severe encephalopathy. His medical history revealed neonatal asphyxia due to accidental birth outside the hospital and neonatal infection. A sister had died at age 4 years with similar neurologic features. Clinical examination revealed spastic tetraparesis, failure to thrive, microcephaly (-3 SD), and absence of psychomotor development.
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