Abstract
For the past 50 years, free radicals have been presumed to be a causal factor of cellular and organismal aging due to their reactive nature. During aging and age-associated disease, there is evidence that free radicals can cause damage to cellular structures. Stem cells and their regenerative potential represent an important therapeutic approach against aging and age-associated diseases. Although in principle stem cells are immortal, there is evidence that their function declines with age. The aging process in stem cells might differ from that of somatic cells, and is unavoidably accompanied by loss or modification of their regenerative capacity. A number of recent papers from different groups uncovered a role of reactive oxygen species in the aging process of stem cells. Here we review the current literature that associates stem cell aging with reactive oxygen species.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
