Abstract
The current study evaluated the antioxidant, α-amylase inhibitory and anti-Staphylococcus aureus activities of the fruiting bodies of Ganoderma lucidum. Methanolic extract of G. lucidum (MEGL) was investigated for its in vitro antioxidant activity using 1,1-diphenyl 2-picrylhydrazyl (DPPH) assay and EC50 value was determined. α-Amylase inhibitory and anti-S. aureus activities were carried out by conventional methods. The mushroom extract showed maximum free radical scavenging activity at a dose of 500 μg/mL with EC50 value of 22.1399 μg/mL. EC50 value for the inhibition of α-amylase activity was found 22.6011 μg/mL. G. lucidum extracts exhibited a concentration-dependent Anti-S. aureus activity. The vast differences of this inhibition between lower and higher doses were assessed significantly (p G. lucidum has moderate antioxidant, α-amylase inhibitory, and anti-S. aureus activities. Thus this mushroom may be the alternative plant source for the antioxidant, anti-diabetic and antibacterial agents and further in vivo studies and isolation of bioactive compounds are required.
Highlights
Medicinal mushrooms have a very long history of traditional uses and are attracting much attention in the nutraceuticals and pharmaceuticals field
This study shows that the fruiting body of G. lucidum has moderate antioxidant, α-amylase inhibitory, and anti-S. aureus activities
Assay of free radical scavenging properties The free radical scavenging activity of Methanolic extract of G. lucidum (MEGL) was determined by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, a method reported by Villano [30]
Summary
Medicinal mushrooms have a very long history of traditional uses and are attracting much attention in the nutraceuticals and pharmaceuticals field. Mushrooms have become impressive as functional foods for their physiologically beneficial bioactive compounds [1]. Important bioactive components reported from the various edible and medicinal mushrooms are polysaccharides, proteins, fatty acids, sterols, polyphenolic compounds, vitamins, and minerals [7] [8] [9] [10]. Several studies revealed that these active components of mushrooms have a favorable impact on human health through the modulating of the immune system, and by their antioxidant and anti-inflammatory activities [1] [2] [3]. Mushrooms can be used as an alternative for prevention as well as treatment of various diseases of mankind
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