Abstract
AbstractThe kinetics of oxidation of an antibacterial drug, methylparaben by permanganate in alkaline medium at a constant ionic strength of 0.80 mol dm−3 was studied spectrophotometrically at 25°C. The stoichiometric ratio between permanganate and methylparaben was found to be 2:1 in alkaline medium. The main products were identified by NMR, IR, and GC–MS spectral studies. The reaction showed first-order kinetics in permanganate, fractional order in methylparaben, and OH− concentrations under the experimental conditions. Ionic strength and dielectric constant did not affect the rate of reaction. The added products did not have any significant effect on the rate of reaction. Based on the rate experimental results, a suitable mechanism is proposed. Investigations at different temperatures allowed the determination of the activation parameters with respect to the slow step of the proposed mechanism. The reaction constants involved in the mechanism were evaluated. The results of this study provide fundamenta...
Highlights
Bioinorganic chemistry constitutes the discipline at the interface of the more classical areas of inorganic chemistry and biology
Reaction orders The oxidation of methylparaben by potassium permanganate in alkaline medium, proceed with measurable rates
The reaction orders have been determined from the slopes of log kobs vs. log plots by varying the concentrations of methylparaben and alkali in turn while keeping others constant
Summary
Bioinorganic chemistry constitutes the discipline at the interface of the more classical areas of inorganic chemistry and biology. The permanganate ion (MnO−4) can oxidize a great variety of substances and it finds extensive applications in organic synthesis (Lee, 1980; Lee, Lee, & Brown, 1987; Simandi, Jaky, & Schelly, 1984; Wiberg, 1965). The updated literature survey shows that considerable amount of work has been done on the oxidation of organic compounds by potassium permanganate in alkaline media (John & Kee, 1984; Teresa, Maria, & Michal, 1992). The permanganate ion has a tetrahedral geometry with extensive pi-bonding and stable in neutral or slightly alkaline media (Jaky & Simandi, 1981). Permanganate is a versatile oxidizing agent and is used for studying the oxidation kinetics of many organic and inorganic substrates. The mechanisms for different organic substrates suggested by various authors are not similar, indicating that a variety of mechanisms are possible, depending upon the nature of the reactive manganese species, the reaction environment, and the nature of the substrate (Cotton & Wilkinson, 1980)
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