Year-end Sale % OFF 
Abstract
In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis.
Highlights
Breast cancer continues to be a major problem of public health with over 2 million new cases in 2018 world wide[1,2]
We reported the first direct comparison between absorption-based cone-beam breast-CT (CB-CT) and synchrotron radiation phase contrast breast CT (PB-CT) carried out scanning the same mastectomy specimens from two breast cancer patients
PB-CT and CB-CT were both performed with same x-ray dose of about 5 mGy which represented the scanning protocol with the lowest dose at the commercial CB-CT system
Summary
Breast cancer continues to be a major problem of public health with over 2 million new cases in 2018 world wide[1,2]. There is great need to develop alternative imaging strategies that deliver a reduced, or comparable, x-ray dose to patient combined with a reduction in false positives and/or false negatives diagnoses. Such methods should, ideally, remove the physical discomfort of breast compression required for mammography. Phase-contrast CT is an emerging imaging technique that exploits the wave nature of the incident x-ray beam, whereby providing images with a strongly increased contrast-to-noise ratio especially in soft-tissue applications compared to classical attenuation based x-ray imaging[16,17]. We present the first direct comparison between CB-CT and PB-CT on a set of two human mastectomies
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
