Free Papers Compiled

Abstract

Background:Victoria hospital a specialized COVID center in Bangalore saw more than 10,000 patients with COVID-19 infection who have been admitted. Most of them were moderate to severely or critically ill patients who are at risk of developing acute brain dysfunction (delirium). Neurotropism of SARS-CoV-2 and its neurological manifestations have now been confirmed. Hence to find the prevalence, risk factors for developing delirium in patients admitted with COVID-19 infection, was the objective of this research work.Methodology:The study includes 10,200 covid infected patient who were admitted to Victoria hospital, from June 2020 to June 2021. Among them 550 cases were found to have neuropsychiatric symptoms. Patients who were on life support, prisoners, patients were with pre-existing Psychiatric illness, neurodegenerative disorders, congenital or acquired brain damage, hepatic coma, drug dependence (Except ADS and NDS), suicide attempt were excluded. Patients who were blind or deaf were also excluded. Patient demographics, delirium assessments, and management strategies were noted and entered in Microsoft Excel sheets. The outcome was to determine the prevalence of delirium and to find any associated risk factors for delirium the next day.Results:Delirium was diagnosed in 106 patients.The mean age of patients was 60 years.68 % were males & 32 % were females. 80 % of them had medical history, 10 % had past history of Alcohol dependence. 40 % of cases were treated in ICU& 32 % of them were treated on Invasive mechanical ventilation (Ventilators). On investigations, inflammatory markers raised in almost all (C- reactive protein 100 %, D-dimmer 64% and Serum ferritin 69 %). Treatment given was Steroids (Dexamethasone IV) in 100%, Remdesivir in 85 %, Iv antibiotics (Cephalosporin) in 100 %. For Symptomatic delirium treatment Injection Haloperidol IV 1.5 mg to 5mg thrice per day to once daily in 98% cases, some received Quetiapine 12.5 mg to 100mg /day in 5% or Tab Olanzapine 2.5 mg to 10 mg per day in 9% cases. Delirium Mortality rate was 45 % and recovery rate was 55 %.Conclusions:Severe SARS-CoV2 infection may be associated with COVID-19 delirium. High mortality, (more than 50 %) is found in covid delirium patients. Hypoxia could be the main reason for delirium in Covid 19. Elevated inflammatory markers is associated with Delirium in covid 19 patients.