Abstract
Guinea pigs were acutely exposed to different airborne dusts and freshly generated cigarette smoke. The effect was evaluated by counting the number of free lung cells using a lavage method. An exposure to MnO 2 and smoke on the same day caused an increase in the number of leukocytes 24 h thereafter. By increasing the time interval between the MnO 2 and smoke exposure, the effect gradually disappeared. Al 2O 3 or SiO 2 also caused an increase in the number of leukocytes, whereas TiO 2 had no effect. The pathogenesis behind the reaction and the epidemiological implications are discussed.
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