Abstract
We have examined whether d-amino acid oxidase (DAO) regulates free d-serine content using mutant ddY/DAO − mice lacking DAO activity. We find that the content of d-serine in the serum and cerebellum of mutant mice is much higher than that of normal mice, whereas a slight but significant difference in the cerebral d-serine level is observed between the two strains. These results suggest that, although DAO may participate in the catabolism of d-serine in the cerebellum and periphery, there appears to be other mechanisms for catabolism of endogenous d-serine in the brain.
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