Abstract
The occurrence of free high-mannose type N-glycans is well demonstrated in mammalian cells. However, free complex-type N-glycans are not normally observed. Recent glycomic analyses of human cancers have revealed the accumulation of significant amounts of free sialylated complextypeN-glycans in pancreatic and prostate cancers. Specifically, free Neu5Ac-containing complex-type N-glycans were found to accumulate in pancreatic cancers. In addition to these free oligosaccharides, free KDN-containing complex-type N-glycans were found to accumulate in prostate cancers. By contrast, in colorectal cancers, free complex-typeN-glycans were either not detected or accumulated in only trace amounts. As such, these free oligosaccharides are potentially valuable tumor markers.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.