Abstract
The occurrence of free high-mannose type N-glycans is well demonstrated in mammalian cells. However, free complex-type N-glycans are not normally observed. Recent glycomic analyses of human cancers have revealed the accumulation of significant amounts of free sialylated complextypeN-glycans in pancreatic and prostate cancers. Specifically, free Neu5Ac-containing complex-type N-glycans were found to accumulate in pancreatic cancers. In addition to these free oligosaccharides, free KDN-containing complex-type N-glycans were found to accumulate in prostate cancers. By contrast, in colorectal cancers, free complex-typeN-glycans were either not detected or accumulated in only trace amounts. As such, these free oligosaccharides are potentially valuable tumor markers.
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