Abstract
Background Quantitative myocardial T1 mapping and extracellular volume fraction (ECV) show promise for non-invasive assessment of cardiomyopathies. Most available T1 mapping sequences use a single slice breath-hold acquisition with balanced steady state free precession (b-SSFP) readout [1]. However, b-SSFP readout is sensitive to B0 field inhomogeneity and is potentially T2 dependent [1]. In this study, we sought to investigate the feasibility of a free breathing multi-slice T1 mapping sequence using slice-interleaved spoiled gradient echo (GRE) imaging.
Highlights
Quantitative myocardial T1 mapping and extracellular volume fraction (ECV) show promise for non-invasive assessment of cardiomyopathies
The fully recovered longitudinal magnetization is initially acquired for each slice without any inversion recovery (IR) pulse (∞ image)
ECG-triggered single shot acquisitions were used with gradient echo (GRE) readout (TR/TE/a=4.3/2.1ms/10 ̊, FOV=280×272 mm2, voxel size=2×2 mm2, slice thickness=8 mm, 5 slices, 43 phase-encoding lines, linear ordering, 10 linear ramp-up pulses, SENSE factor=2.5, half Fourier=0.75, bandwidth=382Hz/pixel)
Summary
Quantitative myocardial T1 mapping and extracellular volume fraction (ECV) show promise for non-invasive assessment of cardiomyopathies. Most available T1 mapping sequences use a single slice breath-hold acquisition with balanced steady state free precession (b-SSFP) readout [1]. B-SSFP readout is sensitive to B0 field inhomogeneity and is potentially T2 dependent [1]. We sought to investigate the feasibility of a free breathing multi-slice T1 mapping sequence using slice-interleaved spoiled gradient echo (GRE) imaging
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