Abstract
Changes in free amino acids were studied in a rat-isolated cortex preparation using the micro-Dns technique with thin-layer chromatography on polyamide plates. For some amino acids that are putative neurotransmitters in the mammalian central nervous system, the following was observed: Gamma-aminobutyric acid and taurine concentrations, after a pronounced initial decrease, returned to control values after 6 weeks. Glutamic and aspartic acid also exhibited a postoperative decrease. However this was not fully reversed at 6 weeks. On the other hand, glycine and glutamine values were elevated in rat-isolated cortex. The results are compatible with the assumption, for gamma-aminobutyric acid, and tentatively for taurine, of acting as transmitter substances in cerebral cortical interneurons.
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