Abstract
Atherosclerosis is an inflammatory disease of the arterial wall that carries an important socio economic burden. The available data strongly suggest that both innate and adaptive immuno inflammatory mechanisms are the major determinants of plaque complications (called instability). Therefore, most of the important advances in the comprehension of the mechanisms of atherosclerosis came from studies that aimed at the elucidation of the critical components involved in the modulation of the immuno inflammatory response in experimental models of atherosclerosis. Since Thl-driven immune response has been consistently shown to promote atherosclerosis, the general belief is that immuno-modulation through Th2 may be suitable to halt the disease process. Here, we present a novel view of the immuno-inflammatory response in atherosclerosis where the adaptive regulatory response modulates both Thl and Th2 responses and plays a central role in counteracting disease initiation and progression.
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