Abstract
PURPOSE It is important to evaluate hemolytic properties in the development of circulatory artificial organs. Though animal blood have been used as relative hemolysis evaluation, the results highly depend on individuality. We are developing microcapsule suspension, which is expected to be used for absolute hemolysis evaluation instead of animal blood. In this report, we describe fractural characteristics of microcapsule suspension under fluid dynamical shear stress, which is generated by rotational shear stresser developed in our laboratory. METHODS We tested two types of microcapsule suspension, MS-100 (100micrometer diameter and polyurethane membrane) and MS-10 (10micrometer diameter and melamine membrane) under the shearing velocity of 0-15,000s-1 for 15min. These fractural characteristics were compared with the results by bovine blood RESULTS Fractural properties of MS-100 was similar to that of bovine blood, whereas MS-10 showed different result. This tendency depends on the flow condition in the shear stresser. After clarifying the effect of the flow condition, we expect that fractural characteristics under fluid dynamical shear stress can be simulated utilizing microcapsule suspension. This new method leads to absolute hemolytic evaluation.
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