Abstract
A four-step fractionation procedure yields from rat pituitary glands gonadotropic and thyrotropic fractions of relatively high specific activity (about 50 u/mg for TSH, 1.2 u/mg for LH, and 16 u/mg for FSH). Heterothyrotropic activity appears inseparable from gonadotropic (FSH or LH) activity. This result, similar to those of experiments with beef pituitary, conform with a hypothesis according to which mammalian gonadotropins are able to stimulate thyroids of teleost fishes.
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