Fractional Thulium Laser Combined with a Topical Growth Factor Serum Increases Hair Density and Thickness in Male and Female Androgenic Alopecia: A Pilot Study

Abstract

<i><b>Introduction:</b></i> A new treatment consisting of 1927nm fractional laser followed by application of a sterile growth factor solution has potential to treat androgenic alopecia (AGA). We set out to assess the efficacy of 1927nm laser as a topical assisted delivery system with a proprietary growth factor serum to improve androgenic alopecia, as well as to determine the number of treatments needed. <i><b>Methods:</b></i> Ten subjects with mild to moderate AGA had a fiducial point tattooed on the temporal or parietal scalp. The subjects were split into three groups based on the number of treatments. A 1927nm laser was applied to the scalp followed by topical application of the sterile hair growth solution. Clinical and quantified trichoscopic photography were performed at baseline and then at 6, 12, and 24 weeks after the final treatment session. <i><b>Results:</b></i> All 10 subjects reported no side effects and were subjectively satisfied with their result. Hair parameters showed increased hair density and diameter, both achieving statistical significance over the six-month period. There was no difference between the groups of varying numbers of treatments. <i><b>Conclusion:</b></i> Combining fractional 1927nm laser treatments with a growth factor topical solution is safe and effective in the treatment of AGA. Three treatments at 4-weekly intervals is the best choice for treatment protocol.