Fractal Sine Wave of a Histone Reductase Drug Candidate

Abstract

Compounds submitted to the National Cancer Institute undergo in vitro screening against 60 malignant cell lines (NCI60). The screening for our metallized immune complex Toroglobulin showed uniform activity against leukemia lines, but not solid tumors. The drug mechanism of this effect was acknowledged by the screeners to be that of a histone reductase, with a 417 mv. electron transfer measured by cyclic voltammetry on a gold working electrode (1). Such differential cell activity in the screen has been called The Solid Tumor Barrier (2). We then searched to overcome this barrier in order to increase the drug potency and range of Toroglobulin. Experimentation led us to alter Toroglobulin by addition of the amino acids threonine and glycine. We assay the molecular magnetism (spin) by use of a magnetic electrode (Magnetic Sciences) on a Hantek Oscilloscope. This altered Toroglobulin produced a wave train in which one sine wave was integrated with another in fractal symmetry (Fig.1). This new integration with amino acids to produce magnetic sine waves, infers we have magnetic exchange (Exchange Globulin). The resulting periodic oscillation provides an electrochemical model to assay a mode of drug activity. References- US Patent No. 10,472,379 12,2019. Ruthenium Sphingomyelin Complexes and Methods for their Use in the Treatment of Tumors. Palmer, J, Peltier, R, The Solid Tumor Barrier, Proto Magazine, Mass. General Hospital, June 17, 2019. Figure 1