Abstract
A long-established investigation method for in vitro cancer invasion using cancer cell spheroid and normal cell spheroid confrontation for the quantitative determination of invasion was expanded to make use of fractal methods. The box-counting method, the sausage method and a local method were used in comparison with image pre-processing steps such as median filtering, closing and opening, or hole filling and scrapping, and artificially added noise images. It was possible to examine the potential role of the fractal capacity dimension for this invasion model. Several aspects such as the absolute value and variance of the different methods were taken into account and compared to well established quantitative parameters. The fractal approach led to very promising results which improved the determination and examination of the invasion process of cancer.
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