Abstract
Multiple system atrophy-cerebellar (MSA-C) is a degenerative neurological disease of brain. In this study, we used three-dimensional (3D) fractal dimension (FD) method to investigate the structural complexity change of human cerebellum white matter (CBWM) and gray matter (CBGM) for MSA-C disease diagnosis. Twenty patients and twenty-three normal subjects as the control group participated in this study. The T-1 weighted magnetic resonance (MR) images were processed and 3D CBGM and 3D CBGM were analyzed by the FD method. Results demonstrated that the FD values of patients’ CBWM and CBGM decreased significantly, and that their CBWM FD values decreased more significant than that of CBGM. Results also showed that the 3D FD method was superior to the conventional volumetric method in terms of better reliability, accuracy, and sensitivity.
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