FP07.03 Diagnostic Potential of Novel Mesothelioma-Specific MicroRNAs

Abstract

One of the main challenges in diagnosing malignant pleural mesothelioma (MPM) is the differential diagnosis between MPM and other cancers, especially lung adenocarcinoma, that have metastasized to the pleura. Tissue-specific biomarkers could overcome this issue, and in particular microRNAs have been suggested to be very useful in this context, with several studies suggesting that many tissue-specific microRNAs remain to be annotated. Recently, an in-depth analysis of the TCGA small-RNA sequencing data of 87 MPM tumours identified previously undetected microRNAs that could distinguish MPM from non-small cell lung cancer (Martinez VD et al, AJRCM 2019: 61(2)).