Abstract
Background: FoxP3, PD-1 and CTLA-4 are upregulated in chronic viral infections, such as chronic HCV, chronic HBV and HIV infection. Materials & methods: During 1 year of tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B, we investigated the expression of FoxP3, PD-1 and CTLA-4. Peripheral blood mononuclear cells were isolated from the 30 study subjects at T0 (0 months), T3, T6 and T12 months after the commencement of TDF treatment. Results & conclusion: Expression of FoxP3, PD-1 and CTLA-4 was significantly decreased in T cells of patients with chronic hepatitis B under TDF treatment at T12, when compared with that at T0. A direct correlation was observed between FoxP3 and CTLA-4 expression in patients with chronic hepatitis B and the frequency of FoxP3 was positively associated with serum alanine aminotransferase levels.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.