Abstract
FOXP3 is a promising and potential candidate gene in generalised vitiligo susceptibility.
Highlights
Vitiligo, the very frequent ancient idiopathic dermatological disorder is characterized by chronic and progressive autoimmune loss of melanocytes from the basal layers of the epidermis that results in white macules on the affected skin
To recognize genes that mediate in vitiligo susceptibility, diverse approaches such as gene expression analyses, candidate gene association, genome-wide linkage, and genome wide association studies have been exploited (Allam and Riad, 2013)
The autoimmune loss of pigmentation is allied with infiltrates of T cells and macrophages, and the progression of the disease is due to the decreased CD4+/CD8+ cell ratio which is cytotoxic to melanocytes (Lili et al, 2012)
Summary
The very frequent ancient idiopathic dermatological disorder is characterized by chronic and progressive autoimmune loss of melanocytes from the basal layers of the epidermis that results in white macules on the affected skin. The crucial master transcription factor that regulates the fate and identity of Treg cells which play an imperative role in preventing autoimmunity is forkhead box protein 3 (FOXP3).
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