Abstract
GENERAL COMMENTARY article Front. Cell. Neurosci., 13 November 2014Sec. Cellular Neurophysiology Volume 8 - 2014 | https://doi.org/10.3389/fncel.2014.00387
Highlights
Edited by: Dirk Schubert, Radboud University Nijmegen Medical Centre, Netherlands Reviewed by: Nael Nadif Kasri, Radboud University Nijmegen Medical Centre, Netherlands
Devanna et al.’s study adds to the literature showing that retinoic acid (RA) plays an important role in brain plasticity (Luo et al, 2009), learning and memory (Etchamendy et al, 2003; Jiang et al, 2012), and we find this research direction promising
One of the RUNX2 targets is CRABPII (Wu et al, 2014), a RA signaling component highlighted by Devanna et al Another target of RUNX2, and a gene regulated by RA, is HES1 (Suh et al, 2008)
Summary
Edited by: Dirk Schubert, Radboud University Nijmegen Medical Centre, Netherlands Reviewed by: Nael Nadif Kasri, Radboud University Nijmegen Medical Centre, Netherlands. FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways by Devanna, P., Middelbeek, J., and Vernes, S. Devanna et al (2014) have demonstrated that FOXP2 mimics, and potentiates, retinoic acid (RA) induction of genes involved in neural differentiation.
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