Abstract
Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers can aid in more accurate prediction of clinical outcome and may also reveal novel predictive factors and therapeutic targets. One such prognostic marker seems to be FOXA1. Many studies have shown that FOXA1 is strongly expressed in a vast majority of cancers, including breast cancer, in which high expression is associated with a good prognosis. In this review, we summarize the role of this transcription factor in the development and prognosis of breast cancer in the hope of providing insights into utility of FOXA1 as a novel biomarker.
Highlights
Breast cancer is the most common type of female malignancy all over the world
Many studies have shown that forkhead-box protein A 1 (FOXA1) is strongly expressed in a vast majority of cancers, including breast cancer, in which high expression is associated with a good prognosis
We summarize the role of this transcription factor in the development and prognosis of breast cancer in the hope of providing insights into utility of FOXA1 as a novel biomarker
Summary
Breast cancer is the most common type of female malignancy all over the world. Despite improvement in surgical techniques and oncology treatments, the prognosis of breast cancer is still poor (Desantis et al, 2013). Knowing why and how some ER-positive breast cancers behave differently than others are important for both research and clinical viewpoint One such prognostic markers and novel therapeutic targets seems to be forkhead-box protein A 1 (FOXA1). As a member of the fox family of transcription factors, FOXA1 express in the liver, and in the breast, pancreas, bladder, prostate, colon and lung and can bind to the promoters of more than hundred genes associated with regulation of cell signaling and the cell cycle (Wolf et al, 2007). In addition to modulating ER activity, FOXA1 directly binds to the ESR1 (oestrogen receptor 1) promoter and is required for expression of ER mRNA and protein in breast cancer cells (Bernardo et al, 2010). NHAER, n2o, thaupmplaincaebpleid; eIHrmCa,limremceupntoohr i2st;oEchGeFmRis,treyp;idLeVrmI, alylmgprohwovthasfcaucltaorrinrevcaespiotonr;;ECRK, e1s4t,rocgyetnokreecraetpintor1;4P;RC,Kpr5o/g6e, sctyertookneerraetcinep5to/6r;;75.0 apositive correlation; bnegative correlation
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