Abstract
A 42-year-old woman presented to the Department of Dermatology & Venereology, Virgen de las Nieves Hospital, Granada, Spain, in May 2015 with a severe pruritic rash and hair loss in both axillary regions. Physical examination showed skin coloured papules and alopecia [Figure 1A], which showed no fluorescence under a Wood’s lamp. Dermoscopy revealed hair follicle-centred papules, traumatised terminal hairs and blackheads [Figure 1B]. The histology of the skin biopsy indicated an inflammatory infiltrate of lymphocytes affecting the follicle [Figure 1C] and the obstruction of the eccrine and apocrine sweat glands [Figure 1D]. The patient was diagnosed with Fox-Fordyce (FF) disease. Following treatment with tretinoin (0.05%), she demonstrated moderate symptomatic improvement. Figure 1A–D: A 42-year-old woman with Fox-Fordyce disease with (A) skin coloured papules of 1–2 mm and moderate alopecia in the right axilla and (B) folliculocentric papules with a few traumatised terminal hairs and blackheads. Haematoxylin and eosin stains ...
Highlights
Haematoxylin and eosin stains showed (C) inflammatory infiltrate of lymphocytes affecting the follicle at x10 magnification and (D) eccrine and apocrine sweat glands showing dilatation at x4 magnification
A42-year-old woman presented to the Department of Dermatology & Venereology, Virgen de las Nieves Hospital, Granada, Spain, in May 2015 with a severe pruritic rash and hair loss in both axillary regions
The histology of the skin biopsy indicated an inflammatory infiltrate of lymphocytes affecting the follicle [Figure 1C] and the obstruction of the eccrine and apocrine sweat glands [Figure 1D]
Summary
Haematoxylin and eosin stains showed (C) inflammatory infiltrate of lymphocytes affecting the follicle at x10 magnification and (D) eccrine and apocrine sweat glands showing dilatation at x4 magnification. A42-year-old woman presented to the Department of Dermatology & Venereology, Virgen de las Nieves Hospital, Granada, Spain, in May 2015 with a severe pruritic rash and hair loss in both axillary regions.
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