Abstract
Fourier transform Raman and infrared spectra of four compounds closely related to diazepam (Valium) were recorded in the solid state, namely nitrazepam, nimetazepam, clonazepam and flunitrazepam, all of which have a nitro group at position 7 in the 1,4-benzodiazepine structure. The spectra show characteristic features associated with both the diazepine ring and substituents. The Raman and infrared spectra all have a very strong band near 1340 cm −1, which is assigned to the symmetric stretching mode of the NO 2 group. A strong line near 1610 cm −1 in the Raman spectra is assigned to the C = N stretch of the diazepine ring and the very strong IR absorption near 1690 cm −1 is attributed to the C=O stretching mode. Evidence for intermolecular hydrogen bonding in nitrazepam and clonazepam is presented.
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