Fourier Analysis on Irregular Corneal Astigmatism Using Optical Coherence Tomography in Various Severity Stages of Keratoconus

Abstract

To investigate the diagnostic capability of Fourier indices in detecting clinical or subclinical keratoconus (KC). Prospective cross-sectional study. The study included 126 eyes with clinical KC (50 KC without any corneal scar, 50 KC with anterior corneal scar, and 26 KC with posterior scar having a history of acute corneal hydrops), 50 with topographic KC (without clinical signs), 50 with pre-topographic KC (normal topography without clinical signs), and 50 controls. Corneal tomographic data were obtained using anterior segment optical coherence tomography (OCT). Fourier analysis decomposed dioptric data from both anterior and posterior corneal surface into spherical, regular astigmatism, asymmetry, and higher-order irregularity components. The discriminating ability of the Fourier indices of pre-topographic KC, topographic KC, and clinical KC from controls were assessed after quantitative Fourier analysis of irregular corneal astigmatism. Posterior asymmetry and higher-order irregularity components were significantly greater in pre-topographic KC eyes than those in controls (P < .001 for both), with the highest area under the receiver operating characteristic curve (AUROC) of 0.778 and 0.709, respectively. The same was true for anterior asymmetry, posterior asymmetry, and posterior higher-order irregularity components in topographic KC (AUROC of 0.945, 0.941, and 0.893, respectively), whereas it was >0.948 for all Fourier components in clinical KC. Fourier analysis using OCT can evaluate anterior and posterior corneal irregular astigmatism of various KC stages, from very mild to advanced, including severe cases with corneal scar. Irregular astigmatism indices from the posterior corneal surface showed the highest AUROC values in discriminating early KC stages.