Abstract
Four pentasaccharide resin glycosides, acutacoside F–I (1–4), were isolated from the aerial parts of Argyreia acuta. These compounds were characterized as a group of macrolactones of operculinic acid A, and their lactonization site of 11S-hydroxyhexadecanoic acid was esterified at the second saccharide moiety (Rhamnose) at C-2. The absolute configuration of the aglycone was S. Their structures were elucidated by established spectroscopic and chemical methods.
Highlights
Resin glycosides, found mostly in plants of the morning glory family (Convolvulaceae), whose structures include fatty acid aglycone and oligosaccharide groups, were partially esterified with different fatty acids
Our previous studies reported that five resin glycosides, acutacoside A–E, were obtained from the plant, and some of which showed potential inhibition against α-glucosidase. [14,15]
Compounds 1–4 were separated from the dried aerial parts of A. acuta with several chromatograph methods
Summary
Found mostly in plants of the morning glory family (Convolvulaceae), whose structures include fatty acid aglycone and oligosaccharide groups, were partially esterified with different fatty acids. (Convolvlaceae) is a climbing shrub, known as twining vine It is widely distributed in Guangdong and Guangxi province in China, and is used as folk medicine for dispelling wind; eliminating dampness; relieving cough; reducing sputum; stopping bleeding and promoting tissue regeneration; relaxing and activating the tendons; and removing toxicity to eliminate carbuncles. These new compounds, macrolactones of operculinic acid A, were partially esterified with different fatty acids. The lactonization site of the agylcone, jalpinolic acid, was attached to the second saccharide moiety (Rhamnose) at C-2. Their structures were elucidated on the basis of extensive spectroscopic data interpretation and chemical degradation.
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