Abstract
Four new oplopane and guaiane type sesquiterpenoids (1–3), and a monoterpenoid (4) together with three known monoterpenoids (5–7), have been isolated from the roots of Ligularia narynensis. The structures of 1–4 were elucidated as 3β,4-diacetoxy-8α-(2-methylbutyryloxy)-9α-(4-methylsenecioyloxy)-11α,12-epoxyoplop-10 (14)-ene (1), 3β,4-diacetoxy-9α-(4-acetoxy-4-methylsenecioyloxy)-2β,8α-di (2-methylbutyryloxy)-11α,12-epoxyoplop-10 (14)-ene (2), 2α-hydroxy-1βH,7αH,10αH-guai-4,11 (12)-dien-3-one (3) and 1α,2β,3α,6α-tetrahydroxy-p-menthane (4) by spectroscopic methods. 1 and 2 were evaluated for their in vitro cytotoxic activity against cultured SMMC-7721 (human hepatoma), L02 (human hepatocyte), and HL-60 (human promyelocytic leukaemia) cell lines.
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