Abstract
Hyperibrins A−D (1–4), polycyclic polyprenylated acylphloroglucinol derivatives, were identified from air-dried aerial parts of Hypericum scabrum. All structures were determined by NMR spectroscopic methods and experimental and calculated ECD spectra. Compounds 1, 3, and 4 showed significant neuroprotective effects on glutamate-induced toxicity in SK-N-SH cells. Additionally, compounds 3 and 4 showed moderate hepatoprotective activities against paracetamol-induced HepG2 cell damage.
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