Abstract
Four new diterpenoid alkaloids, nagaconitines A-D (1–4), were isolated from the roots of Aconitum nagarum var. heterotrichum. Their structures were elucidated as 8-(4′-hydroxylbutyryl) aconitine (1), 15-oxo-13-deoxyludaconitine (2), 15-hydroxyldelphisine (3), and 14-hydroxyl-2- acetoxyspiradine C (4) based on extensive UV, IR, MS, 1D NMR and 2D NMR analyses. Compounds 3-4 showed inhibition of cancer cell line SK-OV-3 with 31% (IC50 43.78μmol/L) and 24% (IC50 32.14μmol/L), respectively.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
