Abstract
Four new benzoylamide derivatives, lepidiumamide B–E (1–4), were isolated from the seeds of Lepidium apetalum Willd. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury.
Highlights
The seeds of Lepidium apetalum Willd. have been used as traditional Chinese herbal medicine for the treatment of lung disorders, such as dyspnea, cough, abundant expectoration, and symptoms in which the lung is blocked due to phlegm retention [1]
11 uridine derivatives were isolated from the seeds of L. apetalum [14,15]
The isolation and structural elucidation of the new compounds, as well as their protective effects against NRK-52e cell injury induced by LPS, are described
Summary
The seeds of Lepidium apetalum Willd. have been used as traditional Chinese herbal medicine for the treatment of lung disorders, such as dyspnea, cough, abundant expectoration, and symptoms in which the lung is blocked due to phlegm retention [1]. Have been used as traditional Chinese herbal medicine for the treatment of lung disorders, such as dyspnea, cough, abundant expectoration, and symptoms in which the lung is blocked due to phlegm retention [1]. The dry mature seeds of L. apetalum and Descurainia Sophia (L.) WebbexPrantl., belonging to Cruciferae (Brassiaceae) family, were commonly called “Tinglizi”, and the former was called “Bei Tinglizi”, and the latter was named “Nan Tinglizi” in the Chinese Pharmacopoeia 2015 [3]. They have both been used as “Tinglizi”; there were distinctions between their plant origin, appearance, and pharmacological activity [4].
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