Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique.

Yang-Yang Liu,Jian-He Wei,Yun Yang,De-Li Chen,Wei Zheng,Jian Feng,Zheng Zhang

doi:10.3390/molecules21111433

Abstract

Four new 2-(2-phenylethyl)chromone derivatives (1–4) were isolated from the EtOH extract of Chinese agarwood produced via the whole-tree agarwood-inducing technique, coming from Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae). Their structures were elucidated by extensive spectroscopic methods, such as UV, IR, MS, 1D as well as 2D NMR. All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7. Compound 1 exhibited significant inhibitory activity with an IC50 value of 4.6 μM.

Highlights

IntroductionAgarwood or eaglewood ( known as chen xiang in China, agar in India, oud in the Middle East, gaharu in the South East Asia and jinkoh in Japan) is the resinous wood of the Aquilaria spp. trees
Agarwood or eaglewood is the resinous wood of the Aquilaria spp. trees
The results showed that compound 1 showed significant inhibitory activities with IC50 value of 4.6 μM and compound 3 displayed moderate activity with IC50 value of 84 μM comparing of the positive drug control group aminoguanidine with

Summary

Introduction

Agarwood or eaglewood ( known as chen xiang in China, agar in India, oud in the Middle East, gaharu in the South East Asia and jinkoh in Japan) is the resinous wood of the Aquilaria spp. trees. It is an angiosperm existing in the Thymelaeaceae family [1]. Our laboratory has patented an effective method, which is the whole-tree agarwood inducing technique (Agar-Wit) [2,5,6], in China It is currently being filed for international patent.

2.Results

C AB compound

C18 Hsignals

General Experimental Procedures

Plant Material

Extraction and Isolation