Abstract
Chisocheton balansae C.DC., is one of the Meliaceae family plants which is the endemic plants from Soputan Mountain, North Sulawesi, Indonesia. This study was aimed to determine the chemical structure of flavan-3-ol compounds from ethyl acetate extract of C. balansae C.DC stembark. Dried powder of C. balansae C.DC stem bark was extracted consecutively with n-hexane, ethyl acetate, and methanol solvents. Four flavan-3-ol compounds, named catechin (1), epicatechin (2), epigallocatechin-3-O-gallate (3), and epicatechin-3-O-gallate (4) were successfully isolated from ethyl acetate extract. The chemical structure of these isolates was determined by spectroscopic methods (1H-NMR, 13C-NMR, DEPT, and 2D-NMR) and comparison with previous reported spectral data. These compounds are first time reported from this plant.
Highlights
Chisocheton is one of the genera of the Meliaceae family, which has 53 species mainly distributed in tropical and subtropical regions such as southern China, Thailand, Malaysia, Vietnam, Indonesia and northern Australia (Shilpi et al, 2016; Zhang, He, Wu, Chen, & Yue, 2012)
In our continuous effort to discover interesting molecules from the Chisocheton plant, this study revealed the presence of flavan-3-ol compounds from C. balansae C
Balansae C.DC was chromatographed over vacuumliquid chromatography (VLC) and silica gel column chromatography to afford compounds 1, 2, 3 and 4 (Figure 1)
Summary
Chisocheton is one of the genera of the Meliaceae family, which has 53 species mainly distributed in tropical and subtropical regions such as southern China, Thailand, Malaysia, Vietnam, Indonesia and northern Australia (Shilpi et al, 2016; Zhang, He, Wu, Chen, & Yue, 2012). The ethyl acetate extract (122.1 g) was separated by vacuum liquid chromatography (VLC) packed with silica gel G60 by gradient elution of CH2Cl2-EtOAc-MeOH (100:0:0 – 0:0:100) to give ten fractions (A-J). Fraction F (2.99 g) was separated using n-hexane: EtOAc (5:5) with 1% addition of concentrated formic acid afforded compound 1 (23.1 mg) and compound 2 (4.2 mg).
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