Abstract

There is little information on chronic obstructive pulmonary disease (COPD) mortality trends, age of death, or male:female ratio. This study therefore sought to analyze time trends in mortality with COPD recorded as the underlying cause of death from 1980 through 2017, and with COPD recorded other than as the underlying cause of death. We conducted an analysis of COPD deaths in Galicia (Spain) from 1980 through 2017, including those in which COPD was recorded other than as the underlying cause of death from 2015 through 2017. We calculated the crude and standardized rates, and analyzed mortality trends using joinpoint regression models. There were 43,234 COPD deaths, with a male:female ratio of 2.4. Median age of death was 82 years. A change point in the mortality trend was detected in 1996 with a significant decrease across the sexes, reflected by an annual percentage change of −3.8%. Taking deaths into account in which COPD participated or contributed without being the underlying cause led to an overall 42% increase in the mortality burden. The most frequent causes of death when COPD was not considered to be the underlying cause were bronchopulmonary neoplasms and cardiovascular diseases. COPD mortality has decreased steadily across the sexes in Galicia since 1996, and age of death has also gradually increased. Multiple-cause death analysis may help prevent the underestimation of COPD mortality.

Highlights

  • Available studies indicate that there has been a decline in chronic obstructive pulmonary disease (COPD) mortality since the 1990s, especially among men [5,6], though it is not known exactly when this decrease began because there are no long-term time series data [7]

  • We performed an analysis of deaths due to COPD among persons aged 35 years and over in Galicia (NW Spain) across the period 1980–2017, using data sourced from the Galician Regional Deaths Register

  • 30,383 deaths occurred in men, with a male mortality ratio (MR) of 2.4

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Summary

Introduction

COPD prevalence varies widely among countries, in Spain, the cross-sectional study EPISCAN II aimed at estimating COPD prevalence showed that it was 12% among adults over the age of 40 years [3]. These data are very similar to those reported by the Global Burden of Disease, which estimated a global prevalence of 11.7% [4]. COPD gives rise to high mortality, estimated at 3.17 million deaths worldwide in 2015, accounting for 5% of total mortality [4]. Available studies indicate that there has been a decline in COPD mortality since the 1990s, especially among men [5,6], though it is not known exactly when this decrease began because there are no long-term time series data [7]

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