Four Cousins with Hypospadias, Is It Familial or Environmental? (Case Report)

Mohamed Elsayed Mohamed Mohamed,Yousef Abdalazeem,Mina Senada,Mohamed Ahmed Hassan

doi:10.4236/mps.2019.93008

Abstract

Hypospadias is one of the most common birth defects. However, its etiology remains largely unknown. Genetic and also intrauterine environmental factors have a principal role in causing familial hypospadias. Hypospadias repair is done through several techniques, one of which is Snodgrass technique which has many advantages. The 4 cousins underwent repair with no complications during 6 months follow up period. Methods: Urethroplasty using Snodgrass hypospadias repair of 4 cousins with positive parental consanguinity and absent family history of hypospadias. Results: 4 cousins underwent Snodgrass (Tubularized incised plate urethroplasty) with no complications after 6 months follow up. Conclusion: Although there is high heritability of hypospadias that also aggregates within second- and third-degree relatives, environmental factors may play a principal role in causing familial hypospadias. Hypospadias repair has a long learning curve. The continuous auditing should be done to improve the results.

Highlights

Hypospadias is the most common congenital abnormality affecting the male urethra, with a worldwide incidence of about 1:300 live male births
Genetic and intrauterine environmental factors have a principal role in causing familial hypospadias
Conclusion: there is high heritability of hypospadias that aggregates within second- and third-degree relatives, environmental factors may play a principal role in causing familial hypospadias

Summary

Introduction

Hypospadias is the most common congenital abnormality affecting the male urethra, with a worldwide incidence of about 1:300 live male births. Hypospadias is the abnormal location of the urethra on the ventral surface of the penis [1] [2]. The etiology of hypospadias in the majority of cases remains unknown. Fewer than 5 percent of all cases of hypospadias may be associated with such conditions. The goal of hypospadias repair is to create a straight penis with a slit-like meatus at the tip of the glans and a urethra of uniform caliber and adequate length, reconstructing a symmetrical glans and penile shaft and achieving projectile stream and normal erection [10]

Case Report

Discussion

Findings

Conclusion