Four cases of transient neonatal diabetes mellitus

Abstract

Objective To reveal the clinical features of children with transient neonatal diabetes mellitus(TNDM) in order to provide a basis for the TNDM treatment strategy formulation. Methods Four patients diagnosed as TNDM hospitalized in Beijing Children's Hospital Affiliated to Capital Medical University from Dec. 2008 to Dec. 2010 were chosen as research subjects. Their clinical data were analyzed retrospectively. Results The 4 patients diagnosed as TNDM started insulin therapy. Two cases of the 4 patients transferred from insulin to oral Sulfonylureas for 2-3 weeks after their conditions became steady. One patient was treated with Sulfonylureas successfully and the other one was partially effective with this therapy. After 2 to 3 years follow-up, 3 cases remitted in 1 month after birth with no other severe complications, one case lost. Conclusions Infants with TNDM had unique clinical features. The patients develop diabetes in the first few weeks of life but go into remission in a few months. So the follow-up for those TNDM patient is very essential for clinical classification. Oral glibenclamide therapy seems highly effective and safe for some TNDM patients. Key words: Transient neonatal diabetes mellitus; ATP-sensitive potassium channels; Sulfonylureas