Abstract
Dear Editor: Dysplastic nevus syndrome (DNS), also known as atypical mole syndrome, has been a source of considerable controversy because of the confusion about its nomenclature and definition. DNS is known to be rare in Asia, and to our knowledge, it has hardly been reported in Korea1,2. However, in previous reports on dysplastic nevi (DN) in Korean individuals, 1 case from Roh et al.1 and 9 of 15 cases from Shin et al.2 satisfied the definition of DNS from our viewpoint. Herein, we report 4 additional cases of DNS in Korean patients, including 2 cases of melanoma that developed, and were reviewed in the above Korean reports. Three male patients and a female patient presented with multiple asymmetric, ill-defined and variegated colored nevi (Fig. 1A~C, F). Their age ranged from 22 to 42 years old and the number of lesions was 5 to 21. Among the patients, patient 2 had a history of malignant melanoma that developed from a congenital melanocytic nevus, and patient 3 had a nodular melanoma that developed from DN (Fig. 1D, E). The father of patient 4 was diagnosed with nevoid melanoma with fatal metastasis. Histopathological examinations were performed on the lesions clinically suspected to be DN in each patient. All biopsy samples showed lentiginous melanocytic proliferation along the elongated epidermal rete ridges at the dermo-epidermal junction (DEJ) (Fig. 2A). On magnifying view, mild to moderate cytological atypia of random pattern and dusty melanin granules were found at the DEJ in the dermis. Fibroplasia of the concentric and lamellar type was also observed around the elongated rete ridges and the upper dermis (Fig. 2B). Immunohistochemical staining revealed HMB-45-positive melanocytes (Fig. 2C) and a mean value of 7% Ki-67-positive cells (Fig. 2D). A final histopathological diagnosis of compound dysplastic nevus was made for patients 1, 3, and 4, and junctional DN for patient 2. However, melanoma that developed from DN was also present in patient 3 (Fig. 2E~G). Considering both the clinical and histopathological features, we diagnosed all these cases as DNS. Furthermore, we performed excision only in cases of considerable DN that either presented unusual clinicopathological features or where the patient strongly wanted the DN to be removed. For the others, close observation was recommended. Fig. 1 (A) Patient 1: multiple clinical dysplastic nevi (DN) on the back. (B) Patient 2: several clinical DN on the left arm. (C) Patient 3: clinical DN on the scalp; (D) a solitary enlarging black plaque on the right leg that was particularly diagnosed as a ... Fig. 2 Representative histopathologic features of patient 4. (A) Lentiginous melanocytic proliferation along the elongated epidermal rete ridges and rete fusion at the lower tip, with concentric and lamellar fibrosis in the papillary dermis (H&E, ×100). ... Concerning the various definitions, there is considerable debate about the number of DN. Most previous reports agreed that large numbers of DN should be included in the diagnostic criteria. However, Elder et al.3 described DNS as a wide spectrum of clinical phenotype from a single DN in a patient without a personal and family history of melanoma to familial atypical multiple molemelanoma syndrome. As we have followed Elder's definitions, we classified even 5 DN as DNS. In analyzing previous cases1,2, all 10 cases could not be analyzed according to asymmetry, border, and color because of a lack of description. However, their size was 3~45 mm, except in 1 case. Although the DN in 1 patient had a minimum size of 3 mm, as the number of DN was as many as 406, we considered this patient as having DNS. Considering that there are no definite clinicopathological diagnostic criteria of DNS in the West, DNS in Korean patients may be underdiagnosed, as previous Korean reports suggest. In addition, a difference in the number of moles between Asian and Western patients with DNS may encourage changing the diagnostic threshold of DN, and more importantly, DNS.
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