Four- and sixteen-month clinical status of a cohort of patients following hospitalization for COVID-19

Abstract

Background and objectivesAlthough many symptoms of post-COVID syndrome have been described, a comprehensive evaluation of their prevalence is lacking. We aimed to describe symptoms at 16 months from hospitalization for COVID-19. MethodsA telephone assessment was performed one year later in a cohort of COVID-19 survivors hospitalized between March and May 2020 and already evaluated four months after discharge. Patients with relevant symptoms at 16 months, patients who presented symptoms at four months, and all intensive care unit patients were invited for assessment at an outpatient facility. At telephone consultation, respiratory, cognitive, and functional symptoms were assessed. Patients underwent pulmonary function tests, lung CT scans, and psychometric and cognitive tests at the outpatient facility. ResultsAmong 478 patients evaluated four months after discharge, 317 (67%) were assessed at telephone consultation and 124 at ambulatory assessment. At telephone assessment, ≥1 new symptom was reported by 216 patients (68%), mainly fatigue (53%), dyspnea (37%), and memory difficulties (24%). Seventy-nine patients (25%) were asymptomatic at four months but declared ≥1 symptom one year later. In patients evaluated twice, the prevalence of cognitive impairment was 45% at four months and 40% at 16 months. Depression and post-traumatic symptoms prevalence remained stable, and the prevalence of anxiety significantly decreased. Dysfunctional breathing was detected in 32% of patients. At 16 months after discharge, lung CT-scan exhibited abnormalities in 30/80 patients (38%), compared to 52/85 patients (61%) at four months. ConclusionAt 16 months after hospitalization for COVID-19, 68% of patients declared symptoms, including patients whose symptoms appeared between 4 and 16 months. Trial registrationClinicalTrials.gov, NCT04704388