Abstract
Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A–D (1–4), were isolated from the roots of Kadsura coccinea, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of 1 was ambiguously verified by single-crystal X-ray diffraction, while the structure of 2, which features a novel 8,16-epoxy motif, was validated by quantum chemical calculation of NMR parameters and ECD spectrum. Moreover, 1 and 4 were found to exhibited anticoagulant activity, while 3 and 4 were found to possess anti-platelet aggregation activity.
Highlights
The plants of family Schisandraceae, including genera Schisandra and Kadsura, are invaluable sources of triterpenoids [1, 2]
Kadsura coccinea (Lem.) Smith is an economical fruit plant as well as a folk medicine usually employed for the treatment of gastropathy, rheumatic arthritis, postpartum abdominalgia with blood stasis, etc
Phytochemical investigations on the stems of K. coccinea collected from Guangxi and Yunnan Provinces have previously been undertaken by our research group, which revealed this species to be abundant with triterpenoids, especially lanostane triterpenoids [4,5,6,7,8,9]
Summary
The plants of family Schisandraceae, including genera Schisandra and Kadsura, are invaluable sources of triterpenoids [1, 2]. Phytochemical investigations on the stems of K. coccinea collected from Guangxi and Yunnan Provinces have previously been undertaken by our research group, which revealed this species to be abundant with triterpenoids, especially lanostane triterpenoids [4,5,6,7,8,9]. Six kinds of unprecedented lanostane-type triterpenoid scaffolds have been isolated from the stems of K. coccinea by our group. The secondary metabolites of K. coccinea collected from different regions manifested significant differences. It was interesting to consider whether the secondary metabolites from different parts of the same plant differed or not. Considering the folk medicinal value of K. coccinea, some of the compounds were tested for their antiplatelet aggregation and anticoagulant activities.
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