Forty-Hertz light oscillations did not change the natural fear behavior of the 5xfAD mice with looming visual stimuli

Abstract

In recent studiesresearchers have found that gamma oscillations (40Hz) significantly reduced in some neurological diseases. In this article, we will investigate whether the looming stimulation experiment to mice can be used as a way to test the efficacy of 40Hz light stimulation. The results showed that the fearful characteristics displayed by the treated 5xFAD mice, including the response of returning to the nest, freezing, etc. were changed compared with the control group, but did not reach a significant difference. 40Hz light oscillation did not improve the natural fear behavior of 5xFAD mice, and it may be that this physical therapy mode has limited effect on the basic physiological response of AD mice. The effects of intensity and frequency of therapeutic stimulation on the fear cognition of 5xFAD mice will be tested in subsequent experiments.