Abstract
Featured Article: Marbach EP, Weil MH. Rapid enzymatic measurement of blood lactate and pyruvate: use and significance of metaphosphoric acid as a common precipitant. Clin Chem 1967;13:314–25.1 The measurement of oxygen deficits, which is reflected in the onset and severity of lactic acidosis, has had wide application in exercise physiology. Measurement of blood or plasma lactate, specifically the measurement of lactate/pyruvate ratios and subsequently excess lactate, became clinically important assays in the 1960s after these parameters were demonstrated to be of value in the evaluation and management of critically ill and injured patients. The measurements, although laborious and time-consuming, were regarded as quantitative with respect to the severity of anaerobic metabolism and therefore predictive of the prognosis of patients with major impairment in the blood circulation, especially during the states of low blood flow of circulatory shock (1). Reduced oxygen availability …
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